Where Biofreeze has about 4% active ingredient in the roll on variety (we have a Biofreeze spray with 10%), CryoDerm has 10%. It's stronger, and it helps us with neck pain, or for temporary relief around knees and shoulders. This is strong, and would not work for everyone, so you may want to get a sample pack first. I have found this very reasonably priced on Amazon, though I have not located it in person as of yet.
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